Web ads that pop down onto the screen and obscure the text you're reading. Or web ads that expand so that when you scroll down to read something and the ad contracts again, your screen moves and you lose what you were reading. Or, web ads that literally float over the text in such a way that you have to click them away to get rid of them. Web ads that, when you mouse over them, scream at you. Video web ads that just automatically start playing and being distracting as soon as you load a page. Ads that take longer to load than the rest of the page but still prevent you from interacting with what you're reading because of fucking javascript in the ads. Ads disguised as messages from your computer. Ads that pop under the page you're reading but still make your active window inactive so you have to click on it again to scroll down. Ads that, when you click the X to make them go away, spawn new ads that you again have to click to make go away. Ads that appear like commercials when you click to move from one page to another.
Mostly, I hate not having Firefox at work. Firefox makes most of that crap go away.